Enzymes for Commercial Biocatalysis

Iosynth works with some of the best enzyme manufacturers in the world to deliver high quality supply of bulk enzymes for commercial biocatalysis reactions. For some reactions a detailed application protocol is available.

Biocatalysis enzymes from Novozymes

Novozymes is the world leader in industrial enzymes and Iosynth is a Novozymes distributor and close partner of Novozymes in India. We offer the full Novozymes portfolio for biocatalysis to our customers.

Novozymes produces enzymes for almost all applications. Customers around the world trust enzymes from Novozymes on a daily basis. Novozymes is uniquely positioned to offer bulk enzymes at a consistent superior quality and at a competitive price. This piece of mind is particularly useful in biocatalysis applications.


Novozymes Enzymes for Biocatalysis

NOVOZYMES ENZYMES
Novozym 435
Lipozyme CalB L
Novocor AD L
Lipozyme TL 100L
Novozym 51032
Alcalase
Savinase
NOVOZYMES ENZYMES
Promea
Catalase
BAN 480L
Toryzyme 3.0L
Resinase HT
Lecitase Ultra
Palatase 20000L

Novozym 435

Lipozyme CalB L

Novocor AD L

Lipozyme TL 100L

Novozym 51032

Alcalase

Savinase

Promea

Catazyme 25L

BAN 480L

Toryzyme 3.0L

Resinase HT

Lecitase Ultra

Palatase 20000L

If your required Novozymes enzyme is not listed here, please contact us with details.


Enzymes for production of antibiotics

The use of enzymes in the production of antibiotics and beta-lactams is probably one of the most established applications of enzymes in the pharmaceutical industry. The traditional PenG acylase (PGA) is still widely used, but there is also a lot of innovation coming to this segment: Enzymes for new pathways and new classes of antibiotics, as well as innovation in the formulation which allow customers to get more cycles out of their enzymes.

Amicogen Korea is Korea’s number 1 enzyme company and the innovation leader for enzymes in antibiotics. Iosynth represents Amicogen in India and distributes the antibiotic enzyme range

Our enzymes address a very broad portfolio of antibiotics and intermediates (antibiotic building blocks)
ENZYME APPLICATION
Penicillin G acylase 6-APA production from Penicillin G
7-ACCA production from Penicillin G
7-AVCA production from Penicillin G
7-ADCA production from Cephalosporing G
Cephalosporin C acylase Direct production of 7-ACA from CPC (1 step only)
Amoxicillin acylase Amoxicillin production from 6-APA and HPGM
Cephalexin acylase Cephalexin production from 7-ADCA and PGM
Cefaclor acylase Cefaclor production from PGM and 7-ACCA
Cefradine acylase Cefradine production from 7-ADCA and DHME
Cefadroxil acylase Cefadroxil production from 7-ADCA and HPGM
Cefazolin acylase Cefazolin production from TDA and TzAAMe
Cephalosporin C or 7-ACA esterase D-CPC production from CPC
D-7-ACA production from 7-ACA
Cefprozil acylase Cefprozil production from 7-APRA and HPGM

Penicillin G acylase

Cephalosporin C acylase

Amoxicillin acylase

Cephalexin acylase

Cefaclor acylase

Cefradine acylase

Cefadroxil acylase

Cefazolin acylase

Cephalosporin C or 7-ACA esterase

Cefprozil acylase

6-APA production from Penicillin G

Direct production of 7-ACA from CPC (1 step only)

Amoxicillin production from 6-APA and HPGM

Cephalexin production from 7-ADCA and PGM

Cefaclor production from PGM and 7-ACCA

Cefradine production from 7-ADCA and DHME

Cefadroxil production from 7-ADCA and HPGM

Cefazolin production from TDA and TzAAMe

D-CPC production from CPC

Cefprozil production from 7-APRA and HPGM

All our enzymes in this segment have a high substrate selectivity and a high specific activity. For customers this means smooth operation with excellent cost-effectiveness.


Enzymes for specific intermediates

Iosynth has a broad market overview of highly efficient enzymes for specific reactions. These enzymes are ready to be implemented at commercial scale with only minimal R&D activity. Most of these enzymes come with a full tech transfer package to ensure fast implementation while reaching the high technical reaction benchmarks.

Intermediate / API Reaction Details Reaction Scheme Tech Transfer Package available
Pregabalin R-Amide Route Yes
Atorvastatin ATS 6-7 Yes
Phenylepherine Chloro Route Yes
Abacavir - - Yes